ESCHER Next Generation (NG) is an enhanced version of the original ESCHER protein-protein automatic docking system developed in 1997 by Gabriele Ausiello, Gianni Cesareni and Manuela Helmer Citterich. The new release, with a reengineered code, includes some new features:
Protein-protein and DNA-protein docking capability.
Fast surface calculation based on the NSC algorithm. No external software are required.
Only two PDB files are required as input.
Parallel code. ESCHER NG is one of the first docking software that take full advantages of the multiprocessor hardware. Tested on two processor systems, ESCHER runs about 1.8 time faster than an equivalent single processor workstations (same CPU and same clock). These performances can be increased optimizing the code that was not originally developed to the parallel execution. ESCHER NG can run also on single processor systems in sequential mode.
For more information about the method implemented in ESCHER, please refer to the paper: G. Ausiello, G. Cesareni, M. Helmer Citterich, "ESCHER: a new docking procedure applied to the reconstruction of protein tertiary structure", Proteins, 28, 556-567 (1997) .
The Win32 version is included in the latest
VEGA OpenGL package and so if you want it, it's strongly recommended to
download that distribution.
If you need the source code or the other binaries, please download the following distribution:
>>> ESCHER NG 1.2.0 Full Package <<<
Included in the full package:
- Next Generation source code.
- Original source code.
- Windows x86 32 bit binaries optimized for 586, 686, Pentium 3, Pentium 4, K6, Athlon and Athlon with SSE instruction set.
- Windows x64 64 bit binary for Windows XP Professional x64 Edition, Windows Server 2003 x64 Editions and Windows Vista x64 Editions.
- IRIX 6.2 binary for MIPS R4400 or greater.
- Linux x86 32 bit binary.
- Linux AMD64 64 bit binary.
- Amiga OS binaries for 68020/68881 and 68040 (ixemul.library required).
- Localization system for multiple language translations (LocaleLib and FlexxCat).