

REFERENCES
- R. Lowy, B. M.Willumsen et
al., Function and regulation of
RAS, Ann. Rev. Biochem., 62 851-891, 1993.
- R. Schaffer, R. Kim et
al., Genetic and pharmacological
suppression of oncogenic mutations in RAS genes of yeast
and humans, Science, 245 379-385, 1989.
- L. Moores, M. D. Schaber
et al., Sequence dependence of protein
isoprenylation, J. Biol.
Chem, 266 14603-14610,
1991.
- J. Chen, D. A. Andress et
al., cDNA cloning and expression of the
peptide binding beta subunit of rat p21ras
farnesyltransferase, the counterpart of yeast
DPR1/RAM1, Cell, 66 327-334, 1991.
- J. Chen, D. A. Andress et
al., Cloning and espression of a cDNA
encoding the alpha subunit of rat p21ras
farnesyltransferase, Proc.
Nat. Acad. Sci. USA, 88
11368-11372, 1991.
- Reiss, M. L. Brown et al.,
Bivalent cation and prenyl pyrophosphate
specificities of the protein farnesyltransferase from rat
brain a zinc metallo-enzime,
J. Biol. Chem., 267
6403-6408, 1992.
- W. Fu, J. F. Moomaw et
al., Identification of a cysteine
residue essential for activity of protein
farnesyltransferase, J.
Biol. Chem., 271
28541-28548, 1996.
- Reiss, M. C. Seabra et
al., Non identical subunit of p21 HRAS
farnesyltransferase: peptide binding and FPP carrier
functions, J. Biol Chem., 266 10672-10677, 1991.
- B. Gibbs, D. L. Pompliano
et al. A selective inhibition of
farnesyl protein transferase blocks RAS processing in
vivo, J. Biol. Chem, 268 7617-6220, 1993.
- G. L. James, J L.
Goldstein et al., Benzodiazepin peptido
mimetics: potent inhibitors of RAS farnesylation in
animal cells, Science, 260 1937-1942, 1993.
- P. J. Sidebottom, R. M.
Highcock et al., The Squalestatins,
novel inhibitors of squalene synthase produced by a
species of Phoma , J.
Antibiotics, 45 639-658,
1992.
- C. Liu, M. Barbacid et
al., 10'-Desmethoxystreptonigrin, a
novel analog of streptonigrin, J. Antibiotics, 45 454-457, 1992.
- B. Singh, E. T. Jones et
al., Fusidienol: a novel inhibitor of
RAS farnesyl-protein transferase from Fusidium
Griseum, Tetrahedron
Letters, 35 4963-4966,
1994.
- R. Bishop, R. Bond et al,
Novel tricyclic inhibitor of
farnesyl-protein transferase: biochemical
characterisation and inhibition of RAS modification in
transfected cos-cells, J.
Biol. Chem., 270
30611-30618, 1995.
- Park, S. R. Boduluri et
al., Crystal structure of protein
farnesyl transferase at 2.25 Å resolution, Science, 275 1800-1805, 1997.
- Pedretti, A. M. Villa, L.
Villa and G. Vistoli, Interactions of
some PGHS-2 selective inhibitors with the PGHS-1: an
automated docking study by BioDock, Il Farmaco, 52 487-491, 1997.
- Pedretti, A. M. Villa, L.
Villa and G. Vistoli, Modelling of the
interactions of some inhibitors with the PGHS-1 by
BioDock, a stochastic approach to the automated docking
of ligands to biomacromolecules, in Computer-Assisted Lead Finding and
Optimization, Helvetica Chimica Acta Verlag, Basel, 1996.
- Pedretti, Nuovo
metodo per il docking automatico di ligandi con
macromolecole a struttura 3D nota, degree thesis, Milan University, 1995.
- Protein Data Bank, Chemistry Department,
Brookhaven National Laboratory, USA.
- Quanta/CHARMm, MSI,
Burlington, MA, USA.
- Leonard D. M., RAS
farnesyltransferase: a new therapeutic target, Med. Chem., 40 2971-2990, 1997 and references cited
herein.
Please refer to Alessandro Pedretti
Istituto di Chimica Farmaceutica e
Tossicologica
Università di Milano
Viale Abruzzi, 42
I-20131 Milano - Italy
Tel. +39-02-29502230
Fax +39-02-29514197
E-Mail: alex@indigo.farma.unimi.it